M. NOVAC, ALICE VLADOIANU, DANIELA CERNEA, FL. PURCARU
Disciplina ATI , UMF din Craiova
REZUMAT:
Eliberarea citokinelor si a mediatorilorinflamatori la locul leziunii are un efect sistemic odata ce arsura a depasit 30%din suprafata corporala totala.Permeabilitatea capilara este crescuta , ducand la pierdera proteinelor intravasculare si consecutiv a fluidelor in compartimentul interstitial.De asemenea apare vasoconstrictia viscerala si Contractilitatea periferica miocardica este redusa,posibil datorita eliminarii de TNF-α.
Aceste modificari associate hipotensiunea si hipoperfuzia tisulara.Mediatorii proinflamatori duc la bronhoconstrictie,iar in arsurile severe poate apare sindromul de detresa respiratorie.Rata metabolica bazala creste pana de trei ori din valoarea ei bazala.Raspunsul imun antiinflamator apare,el vizand atat celulele mediatoare cat si caile de reglare umorale.
CUVINTE CHEIE mediatori, inflamatori, citokine, arsuri
Systemic reaction în severe burns
ABSTRACT
The release of cytokines and other inflammatory mediators at the site of injury has a systemic effect once the burn reaches 30% of total body surface area. Capillary permeability is increased,leading to loss of intravascular proteins and fluids into the interstitial compartment. Peripheral and splanchnic vasoconstriction occurs. Myocardial contractility is decreased,possibly due to release of alfa tumour necrosis factor .
These changes, coupled with fluid loss from the burn wound, result in systemic hypotension and end organ hypoperfusion.Inflammatory mediators cause bronchoconstriction, and in severe burns adult respiratory distress syndrome can occur. The basal metabolic rate increases up to three times its original rate. Non-specific down regulation of the immune response occurs, affecting both cell mediated and humoral pathways.
Disciplina ATI , UMF din Craiova
REZUMAT:
Eliberarea citokinelor si a mediatorilorinflamatori la locul leziunii are un efect sistemic odata ce arsura a depasit 30%din suprafata corporala totala.Permeabilitatea capilara este crescuta , ducand la pierdera proteinelor intravasculare si consecutiv a fluidelor in compartimentul interstitial.De asemenea apare vasoconstrictia viscerala si Contractilitatea periferica miocardica este redusa,posibil datorita eliminarii de TNF-α.
Aceste modificari associate hipotensiunea si hipoperfuzia tisulara.Mediatorii proinflamatori duc la bronhoconstrictie,iar in arsurile severe poate apare sindromul de detresa respiratorie.Rata metabolica bazala creste pana de trei ori din valoarea ei bazala.Raspunsul imun antiinflamator apare,el vizand atat celulele mediatoare cat si caile de reglare umorale.
CUVINTE CHEIE mediatori, inflamatori, citokine, arsuri
Systemic reaction în severe burns
ABSTRACT
The release of cytokines and other inflammatory mediators at the site of injury has a systemic effect once the burn reaches 30% of total body surface area. Capillary permeability is increased,leading to loss of intravascular proteins and fluids into the interstitial compartment. Peripheral and splanchnic vasoconstriction occurs. Myocardial contractility is decreased,possibly due to release of alfa tumour necrosis factor .
These changes, coupled with fluid loss from the burn wound, result in systemic hypotension and end organ hypoperfusion.Inflammatory mediators cause bronchoconstriction, and in severe burns adult respiratory distress syndrome can occur. The basal metabolic rate increases up to three times its original rate. Non-specific down regulation of the immune response occurs, affecting both cell mediated and humoral pathways.
KEY WORDS cytokines, inflammatory mediators, burns