L. HÎNCU, D. LUPULEASA
Disciplina Industria medicamentului şi Biotehnologii farmaceutice, Facultatea de Farmacie, UMF „Carol Davila” Bucureşti
REZUMAT
Condiţiile de procesare au un efect pronunţat asupra proprietăţilor peletelor cu piroxicam. Ambele mărimi, timpul de sferonizare şi viteza de sferonizare, afectează forma peletelor, iar modificările formei acestora le afectează apoi proprietăţile de curgere.
În cadrul studiului, sfericitatea peletelor a fost mai afectată de timpul de sferonizare decât de viteza de sferonizare. Condiţiile de uscare influenţează friabilitatea peletelor, aceasta scăzând odată cu creşterea temperaturii de uscare, fapt ce indică formarea unor structuri mai dense la temperaturi mai mari. Acelaşi rezultat a fost obţinut prin modificarea timpului de sferonizare. Cu creşterea timpului de sferonizare, a scăzut friabilitatea, din cauza formării unor mase mai compacte la timpi de sferonizare mai mari. Mărimea medie nu a fost afectată de timpul desferonizare sau de viteza de sferonizare.
CUVINTE CHEIE pelete, piroxicam, extrudere– sferonizare
Researches on the obtaining of piroxicam pellets by extrusion – spheronization. Influence of operational variables on the properties of pellets
ABSTRACT
The processing conditions had a pronounced effect on the pellet properties. Drying conditions influenced the mean size and the drug release of the pellets. Because of the shrinking of the pellets upon drying at higher temperatures, the pellets also showed increased densities. Freeze drying almost prevented shrinking and thus led to the highest drug release. With an increase in the temperature of drying, the drug release rate decreased. Both spheronization time and spheronization speed affected the shapes of pellets, and the changes in shapes then affected the pellet flow properties.
Within the studied range, the circularity of the pellets was affected more by the spheronization time than by the spheronization speed. Drying conditions influenced pellet friability, which decreased with an increase in drying temperature, indicating the formation of more dense structures at higher temperatures. The same result was obtained with spheronization time. With an increase in spheronization time, the friability decreased, because of the formation of more compact masses at higher spheronization times. Mean size was not affected by spheronization time or spheronization speed.
Disciplina Industria medicamentului şi Biotehnologii farmaceutice, Facultatea de Farmacie, UMF „Carol Davila” Bucureşti
REZUMAT
Condiţiile de procesare au un efect pronunţat asupra proprietăţilor peletelor cu piroxicam. Ambele mărimi, timpul de sferonizare şi viteza de sferonizare, afectează forma peletelor, iar modificările formei acestora le afectează apoi proprietăţile de curgere.
În cadrul studiului, sfericitatea peletelor a fost mai afectată de timpul de sferonizare decât de viteza de sferonizare. Condiţiile de uscare influenţează friabilitatea peletelor, aceasta scăzând odată cu creşterea temperaturii de uscare, fapt ce indică formarea unor structuri mai dense la temperaturi mai mari. Acelaşi rezultat a fost obţinut prin modificarea timpului de sferonizare. Cu creşterea timpului de sferonizare, a scăzut friabilitatea, din cauza formării unor mase mai compacte la timpi de sferonizare mai mari. Mărimea medie nu a fost afectată de timpul desferonizare sau de viteza de sferonizare.
CUVINTE CHEIE pelete, piroxicam, extrudere– sferonizare
Researches on the obtaining of piroxicam pellets by extrusion – spheronization. Influence of operational variables on the properties of pellets
ABSTRACT
The processing conditions had a pronounced effect on the pellet properties. Drying conditions influenced the mean size and the drug release of the pellets. Because of the shrinking of the pellets upon drying at higher temperatures, the pellets also showed increased densities. Freeze drying almost prevented shrinking and thus led to the highest drug release. With an increase in the temperature of drying, the drug release rate decreased. Both spheronization time and spheronization speed affected the shapes of pellets, and the changes in shapes then affected the pellet flow properties.
Within the studied range, the circularity of the pellets was affected more by the spheronization time than by the spheronization speed. Drying conditions influenced pellet friability, which decreased with an increase in drying temperature, indicating the formation of more dense structures at higher temperatures. The same result was obtained with spheronization time. With an increase in spheronization time, the friability decreased, because of the formation of more compact masses at higher spheronization times. Mean size was not affected by spheronization time or spheronization speed.
KEY WORDS pellets, piroxicam, extrusion– spheronization